Partnerships & Services
Work with us
Carbometrics is looking for collaborations with commercial partners with existing or future interests in continuous glucose monitoring (CGM). We can offer a range of flexible models for collaboration where each party adds value to the other’s technology.
The Platform
Our approach to designing GBMs based CGM sensors is completely novel and distinct from those used in current glucose sensing technologies that rely on boronic acids, proteins or enzymes. The chemical versatility of our platform technology allows us to combine its advantageous selectivity and stability with a wide range of signal transduction techniques (fluorescence, interferometry, electrochemistry, viscometry, osmometry) and realise a highly accurate, interference-free basis for sensing glucose.
The inherent stability of the molecule towards oxidative and chemical degradation means our GBMs have the potential to be used in very long-term glucose sensing applications in challenging environments (e.g. bioreactors or in vivo).
Our platform may be of interest if you are seeking an alternative glucose recognition technology to:
Natural glucose binding proteins (lectins) such as Concanavalin A (ConA)
Enzymes such as glucose oxidase (GOx) or glucose dehydrogenase (GDH)
Synthetic glucose binders based on boronic acids.
We have built up a core team of experienced scientists and industry experts and provided practical and consultancy services to a range of companies.
We have specific and extensive expertise in:
Organic, analytical and polymer chemistry
Purification of complex molecules (macromolecules, peptides and oligonucleotides)
Immobilisation of small molecules to surfaces, polymers and resins
Photo-physical characterisation of fluorophores
Studying molecular binding through a variety of techniques such as NMR spectroscopy, Isothermal Titration Calorimetry, UV-Visible spectroscopy and fluorescence.
Creation of bespoke binding assays using fluorescence-based and electrochemical based techniques (FRET and Cyclic Voltametry).
Want to discuss a partnership
or collaboration with us?
During 2018-2021 we worked with Novo Nordisk, a global leader in diabetes care, to develop a glucose-sensitive artificial insulin through a research collaboration. Leveraging our expertise and glucose binding molecule (GBM) technology, we contributed to the creation of a ground-breaking new insulin that responds to changes in blood glucose levels, a significant step forward in diabetes treatment. Read more about our collaboration using the links below.
Novo Nordisk
Case Studies
“We believe the glucose binding molecules discovered by the Ziylo team together with Novo Nordisk world-class insulin capabilities have the potential to lead to the development of glucose responsive insulins which we hope can remove the risk of hypoglycemia and ensure optimal glucose control for people with diabetes”
Marcus Schindler
SVP of global drug discovery
Novo Nordisk
PyroScience GmbH
PyroScience is one of the world's leading manufacturers of innovative optical pH, oxygen, and temperature sensor technology for industrial and scientific applications. We are currently working together under a research collaboration agreement to develop the world’s first optical glucose sensor for using in bioprocess and cell culture applications.
“For many years we were looking for an optical glucose sensor solution. Existing concepts were not really feasible for reliable usage in industrial applications. The glucose binding molecule (GBM) technology from Carbometrics will be a game changer. Combined with the expertise from PyroScience, this partnership has great potential to deliver the first reliable optical glucose sensor for bioprocessing and cell culture applications.”
Dr Roland Thar
CEO and Co-founder
PyroScience GmbH
Argonaute RNA are pioneering an innovative siRNA platform that uses a novel method of stabilising the siRNA. They are developing RNAi-based therapeutics for a variety of applications. We provided synthetic and analytical chemistry services to aid them in their development of bespoke small molecule-siRNA bioconjugates.
Argonaute RNA
Rosa Biotech is an AI-driven biosensing and diagnostics company developing an array-based differential sensing platform for early detection of disease. We worked with Rosa on an Innovate UK funded project to develop electrochemical probes for their differential sensing platform. Our tailored synthetic molecules helped to enhance the sensitivity and selectivity of their innovative sensor technology.
Rosa Biotech
Epinal is developing a handheld breathalyser to detect if a user is under the influence of narcotics. We provide analytical services to Epinal in order to validate their current biosensors and equipment for the roadside detection of narcotics in breath, helping to tackle the global growing problem of drug-driving.